Effects of alkaloid rich extract of citrullus colocynthis fruits on artemia salina and human cancerous mcf7 and hepg2 cells aniruddha mukherjee, savita d patil abstract in the present research the anticancer effect of alkaloid rich extract of citrullus colocynthis fruits was investigated. This is a dangerously powerful plant that has been found to work as a medicine in ayurveda as well as homeopathy. The subjects were treated daily by powdered seeds of citrullus colocynthis 300 mg and placebo for 6 weeks. The main clinical feature was acute rectorrhagia preceeded by mucosal diarrhea with tenesmus, which gradually progressed to bloody diarrhea and overt rectorrhagia within 3 to 4 hours. It was always known as a toxic gourd but was turned to as a food in desperate times. A read is counted each time someone views a publication summary such as the title, abstract, and list of authors, clicks on a figure, or views or downloads the fulltext. Root density correlated with soil moisture content throughout the depth batanouny and wahab, 1973. Effect of citrullus colocynthis schrad fruits on testosterone. Page designed through the cooperative efforts of interagency itis teams. Citrullus colocynthis definition of citrullus colocynthis. New state records for citrullus, cucumis, and cucurbita cucurbitaceae outside of cultivation in the usa. Pdf tissue culture and plant regeneration of watermelon.
Citrullus colocynthis at encyclopedia of life citrullus colocynthis at national center for biotechnology information. The serums, tg, chol, ldlc, hdlc, sgot and sgpt were measured with enzymatic methods. Colocynth, citrullus colocynthis, hairystemmed perennial vine of the gourd family cucurbitaceae, native to the mediterranean region. Cucurbitacins from the leaves of citrullus colocynthis l. Akobundu authors cherry and simmons are affiliated with the usda.
Jun 14, 2018 citrullus colocynthis, also known as bitter cucumber, is a fruitbearing plant sometimes used medicinally citrullus colocynthis is used to treat diabetes, since it may be able to induce insulin secretion from the pancreas after supplementation, while reducing blood glucose and improving lipid levels. Leg and back pain relief capsicum annuum, colocynthis, gnaphalium polycephalum, magnesia phosphorica tablet out of scope out of scope for rxnorm and will not receive rxnorm normal forms. Starting dose calculation for medicinal plants in animal. Citrullus colocynthis plant has a strong laxative property and application of high dosages of this herbal drug can cause diarrhea, painful cramps, and bloody diarrhea in humans. To examine the safety and efficacy of citrullus colocynthis c. Schrad, which has been used in traditional and ethno medicine of many. Issn phytochemical analysis of a folklore medicinal plant. Thunberg in 1773, show that what thunberg collected is not what has been called. The aqueous and ethanolic extracts of citrullus colocynthis aecc and eecc at. The fruit pulp of colocynth has medicinal properties while the seeds have nutritive qualities. Citrullus colocynthis fruits were also traditionally used as an abortifacient and to treat constipation, oedema, bacterial infections, cancer and diabetes 47.
Citrullus colocynthis, with many common names including colocynth, bitter apple, bitter cucumber, desert gourd, citation needed egusi, vine of sodom, or wild gourd, is a desert viny plant native to the mediterranean basin and asia, especially turkey especially in regions such as izmir, and nubia. Other side effects include convulsions, paralysis, and death. Citrullus colocynthis is a very droughttolerant medicinal species, closely related to. Sciatica therapy arnica montana citrullus colocynthis fruit pulp pseudognaphalium obtusifolium hypericum perforatum potassium iodide magnesium phosphate, dibasic trihydrate toxicodendron pubescens leaf tablet, orally disintegrating number of versions. Roots of a small leptadenia pyrotechnica bush were observed to spread throughout 850 m3 of soil to a depth of 11. Orszagos kemiai biztonsagi intezet egeszsegugyi toxikologiai tajekoztato szolgalat ettsz mergezo anyagok altal okozott tunetek es elvaltozasok budapest 2011 aceton szagu lehelet halitosis a felsorolt. The knowledge on rivers is intensively studied in addition to the distribution of plant diversity, richness of species is also used for effective. Colocynth citrullus colocynthis uses, dosage, side effects.
Files are available under licenses specified on their description page. Dailymed sciatica therapy arnica montana citrullus. Evaluation and characterisation of citrullus colocynthis l. Despite serious safety concerns, colocynth is used for diabetes, high cholesterol and blood fats called triglycerides, constipation, and tuberculosis. Its botanical name is citrullus colocynthis and it belongs to cucurbitacae family. Citrullus is a genus of seven species of desert vines, among which citrullus lanatus the watermelon is an important crop. Sekar abstract phytochemical screening of citrullus colocynthis belonging to the family cucurbitaceae was carried out for finding its medicinal values. Insecticidal activity and biochemical composition of citrullus colocynthis, cannabis indica and artemisia argyi extracts against cabbage aphid.
Citrullus colocynthis an overview sciencedirect topics. The study was designed as a twoarm, doubleblind randomized placebocontrolled. Characterization of watermelon citrullus lanatus var. These compounds include elatermidine, glycosides, resin, dihydric alcohol, heltiacontane, citrullin and citrullinic acid.
Citrullus colocynthis is a medicinal plant that has anticancer property mediated by apoptosis. Minoxidil 2% solution was applied topically and served as the standard. An improved hplc method for determination of colocynthin in. Effect of citrullus colocynthis schrad fruits on testosteroneinduced alopecia. Its small seeds appear in several early egyptian, lybian and near eastern sites from about 4000 bc. The berries have many seeds, or none in the case of the triploid hybrid seedless watermelon 8,10,12. Safety evaluation studies of citrullus colocynthis for. This page was last edited on 23 december 2019, at 06. Chapter 5 discussion the common guava tree psidium guajava is popular in an indigenous system of folk. Sequence information deduced from several polymorphic intergenic cpdna regions and a relatively large intron 0. Despite its promise for the food industry, it is the smallscale, subsistence use that most concerns us here. Effect of citrullus colocynthis on hair growth in albino rats r. Therapeutic effects of citrullus colocynthis fruit in. The authors suggested that combining the use of reflective mulch and host.
As already mentioned, that flour enriches and thickens soups as well as other foods. Known hazards the plant contains a number of potentially toxic compounds and can be harmful if used in quantity. Insecticidal activity and biochemical composition of citrullus. Chemical constituents and pharmacological effects of. Indeed, if you will imagine a watermelon vine bearing a small, hard fruit with a bitter pulp, you. Citrullus colocynthis on integrated taxonomic information system. Pdf the analysis of variation in morphological traits differentiated citrullus colocynthis populations growing north of qena. Phylogeography of the bitter apple, citrullus colocynthis. The benefits, dosage and side effects of citrullus colocynthis. A qualitative analysis was performed for the identification of the presence. Nov 19, 2017 citrullus colocynthis has a number of interesting names like indrayan hindi, bitter apple, vine of sodom, and desert gourd. Persons familiar with the common watermelon vine need no description of the plant which produces colocynth apples. All structured data from the file and property namespaces is available under the creative commons cc0 license.
Toxic effect of citrullus colocynthis on liver ijpt. It is distributed among the west coast of northern africa, eastward through the sahara, until india 6. Pdf topical citrullus colocynthis in painful diabetic. Bitter apple common names bitter apple trees are also known by a host of common. The family also includes pumpkin, squash, melon, and cucumber 3. Chemical, functional, and nutritional properties of egusi colocynthis citrullus l. Effects of hydroethanol extract of citrullus colocynthis on blood. Effects of hydroethanol extract of citrullus colocynthis. The bitter apple is a vinelike plant commonly found in asia and the mediterranean basin. The genus citrullus includes four species, all native to arid regions of africa and eurasia.
Meena and panti, 2008 have isolated and identified quercetin by tlc from citrullus colocynthis linn. Phytochemical analysis of a folklore medicinal plant citrullus colocynthis l bitter apple c. A watermelon can be 570cm long and weigh up to 30kg. To evaluated the differential effects of ethanol extraction of citrullus colocynthis c. Tissue culture and plant regeneration of watermelon citrullus vulgaris schrad.
Intensification of rangeland grazing in an oilrich state. Molecular data, including sequences from the original collection of momordica lanata made near cape town by c. Pdf citrullus colocynthis cct is a medicinal herb known for its multiple. Chemical, functional, and nutritional properties of egusi. It is also used in combination products for treating liver and gallbladder ailments. Citrullus colocynthis cct, also known as bitter apple, wild gourd, tumba and wine of sodom, is known for its medicinal value since long. Solvent extraction of citrullus colocynthis fruit pulp was done by. Citrullus colocynthis is used to treat diabetes, since it may be able to induce insulin secretion from the pancreas after supplementation, while. Colocynthis, bitter apple, bitter cucumber, colocynth. Citrullus colocynthis is a very droughttolerant medicinal species, closely related to watermelon c.
Bitter apple scientific name the scientific name for this plant is citrullus colocynthis. Schrad is a valuable plants from cucurbitaceae family, widely distributed in the barren region, is a nonhardy, herbaceous perennial vine, branched from the base 4. Citrullus colocynthis 2 growth its fruit, which is lemonsized, yellowish, greenmottled, spongy, and extremely bitter, is a powerful hepatic stimulant and hydragogue cathartic. Citrullus colocynthis is a phreatophyte with low tolerance to salinity brown et al. Cucurbitaceae is a valuable plant widely distributed cucurbitaceae is a valuable plant widely distributed in the desert areas of the world including tunisia 6,7. Insulinomimetic effect of citrullus colocynthis roots in stz. Citrullus colocynthis as the cause of acute rectorrhagia.
Effect of citrullus colocynthis on hair growth in albino rats. Schrad is a valuable cucurbit plant, widely distributed in the desert areas of the world. It was banned by the food and drug administration fda in 1991. Mar 20, 2006 citrullus colocynthis is a desert plant with a rich history as an important medicinal plant and as a source of valuable oil. The plant has small, pale greenish yellow flowers, forked tendrils, and. These plants have lemonsized fruits which are known for their medicinal properties. The findings revealed that citrullus colocynthis possess a very strong antihyperglycemic potential justifying. Citrullus colocynthis, also known as bitter cucumber, is a fruitbearing plant sometimes used medicinally. Phenolic compounds and antiradical properties of methanolic extracts of citrullus colocynthis and plantago major in iran afsaneh moslemi mehni 1, fatemeh shahdadi 2 1young researchers and elite club, jiroft branch, islamic azad university, jiroft, iran 2department of food engineering, jiroft university, iran key words. Colocynth citrullus colocynthis is an environmental weed in the northern territory, western australia and victoria. Taking even very small amounts of colocynth can cause severe irritation of the stomach and intestine lining, bloody diarrhea, kidney damage, bloody urine, and inability to urinate.
Pdf genetic diversity of colocynth citrullus colocynthis schrader. It was banned by the food and drug administration in 1991 taking even very small amounts of colocynth can cause severe irritation of the stomach and intestine lining, bloody diarrhea, kidney damage, bloody urine, and inability to urinate. Citrullus colocynthis fruits are generally documented for its broad range of pharmaceutical uses as well as medicinal and. Colocynth definition of colocynth by the free dictionary. Four patients with colocynth intoxication are presented. Citrullus colocynthis fruits are usually recognized for its wide range of medicinal uses as well as pharmaceutical and nutraceutical potential. Effects of alkaloid rich extract of citrullus colocynthis. Phenolic compounds and antiradical properties of methanolic. Citrullus colocynthis contained carbohydrate, protein, separated amino acid, tannins, saponins. Citrullus colocynthis cct fruit also known as bitter cucumber is native to dry areas of north africa, the mediterranean basin and asia. Egusi seed is botanically known as citrullus colocynthis curcurbita citrullus l.
The colocynth grows in sandy, coastal, or desert soils and commonly spreads vegetatively. Homeopathy a homeopathic remedy used for colic, neuralgia caused by suppressed emotions, gastric pain, headaches accompanied by nausea and vomiting, gout, rheumatic complaints, and vertigo. The findings revealed that citrullus colocynthis possess a very strong anti hyperglycemic potential justifying. Out of scope information includes radiopharmaceuticals, contrast media. Alopecia is a psychologically distressing phenomenon. Citrullus colocynthis supplement health benefits, dosage. Hosted by the usgs core science analytics and synthesis.
It is known by various names such as bitter cucumber, pumpkin seeds, egusi melon, vine of sodom plant, wild gourd, bitter apple, colocynth or desert gourd. Colocynth extracts prevent epithelial to mesenchymal transition. There have been reports of death following ingestion of just. Citrullus colocynthis is used to treat diabetes, since it may be able to induce insulin secretion from the pancreas after supplementation, while reducing blood glucose and improving lipid levels.
695 1598 308 240 1078 814 1610 1238 963 1002 861 600 682 750 499 29 898 294 686 747 67 172 1239 1278 627 1443 1320 1190 374 1486 753 565 950 186 628